Bring a large pot of salted water to boil and add the penne and cook according to the package directions, usually about 8 minutes.
While the pasta is boiling, heat a large pan under medium heat and melt the butter and sauté the garlic for about 30 seconds, or until fragrant. Then, add the white wine and season with salt and pepper. Let that cook for about 2-3 minutes until that wine has reduced by half.
Next, add the heavy cream and flake in the smoked salmon. I like to leave some chunks bigger and to mash some up. Cook for additional 2-3 minutes, it's ok if the salmon falls apart.
Once the pasta is done, save 1 cup of pasta water and drain the rest. Add the penne, pasta water, and lemon juice to the pan with the salmon and cook for another minute or two until the sauce thickens and coats the pasta.
Serve with a sprinkle of sea salt, fresh pepper, lemon zest, and parsley.